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Article

Long-term spatiotemporal evolution of drug-resistant Mycobacterium tuberculosis in China.

Nature communications - 27 May 2026

Chen Yiwang, Liang Jialei, Liu Dongxin, Xu Peng, Jiang Qi, Yang Tingting, Liu Qingyun, Takiff Howard E, Gagneux Sebastien, Gao Qian

Abstract excerpt

Antibiotics have been used to treat tuberculosis for over 80 years, yet the long-term evolutionary dynamics of Mycobacterium tuberculosis (Mtb) under antibiotic pressure remain poorly characterized at the population level. Here, we analyze more than 18,000 available Mtb genomes to reconstruct the temporal and spatial evolution of drug resistance across China. We observe that resistance mutations to different...

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Identifiers

PMID: 42204170
DOI: 10.1038/s41467-026-73577-0
PMCID: PMC13408820

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