Article

Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate Carcinomas

2025-11-17

Abstract excerpt

Homologous recombination deficiency (HRD) resulting from inactivation of BRCA1/2 genes promotes chromosomal instability and renders tumor cells susceptible to platinum derivatives and PARP inhibitors (PARPi). The contribution of alterations in other homologous recombination repair (HRR) genes to HRD remains understudied. This investigation aimed to analyze the spectrum of mutations in 34 HRR genes in prostate carc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c67c87c-9a10-5b3c-8221-7150b55b66b7
DOI: 10.20944/preprints202511.1156.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate CarcinomasDOI 10.20944/preprints202511.1156.v1Read

Genomic aberration based molecular signatures efficiently characterize homologous recombination deficiency in prostate cancerSemantic proximity Read

Homologous recombination deficiency and genomic alterations in advanced prostate cancer: insights for precision therapy.Semantic proximity Read

Establishing the homologous recombination score threshold in metastatic prostate cancer patients to predict the efficacy of PARP inhibitorsSemantic proximity Read

Utility of Homologous Recombination Deficiency Biomarkers Across Cancer TypesSemantic proximity Read

Genetic landscape of homologous recombination repair genes in early-onset/familial prostate cancer patientsSemantic proximity Read

Detection of Molecular Signatures of Homologous Recombination Deficiency in Prostate Cancer with or without BRCA1/2 Mutations.Semantic proximity Read

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair–associated gene alterations in solid tumors from a large Asian cohortSemantic proximity Read

Genetic landscape of homologous recombination repair genes in early-onset/familial prostate cancer patients.Semantic proximity Read

Clinical implications of homologous recombination repair mutations in prostate cancer.Semantic proximity Read

Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancerSemantic proximity Read

DNA-Damage-Repair Gene Alterations in Genitourinary MalignanciesSemantic proximity Read

DNA-Damaging Therapies in Patients With Prostate Cancer and Pathogenic Alterations in Homologous Recombination Repair Genes.Semantic proximity Read