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Prevalence and spectrum of homologous recombination repair mutations in patients with metastatic prostate cancer from India.

The oncologist - 6 Mar 2026

Baskarane Hemavathi, Jain Rishabh, Divakar Mohit Kumar, Seth Amlesh, Nayak Brusabhanu, Bakhshi Sameer, Sahoo Ranjit Kumar, Kumar Akash, Sharma Aparna, Kaushal Seema, Haresh Kunhi Parambath, Hooda Vishakha, Vasudeva Payal, Singh Pranav Pratap, Agarwal Rishika, Vasundhara Sanskriti, Agarwal Neeraj, Batra Atul

Abstract excerpt

BACKGROUND: Alterations in genes involved in homologous recombination repair (HRR) occur in approximately 20%-25% of patients with metastatic prostate cancer and are associated with aggressive biology, poor outcomes, and potential sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi). However, frequency and variations in somatic HRR mutations in the Indian population are unknown. METHODS: We analyzed...

Topics

Humans
Male
Prostatic Neoplasms
India
Mutation
Middle Aged
Recombinational DNA Repair
Aged
Prevalence
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ataxia Telangiectasia Mutated Proteins

BRCA2 Protein

BRCA1 Protein

Cyclin-Dependent Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 41729953
DOI: 10.1093/oncolo/oyag059
PMCID: PMC12986755

Genes

ATM
BRCA1
BRCA2
CDK12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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