Article
Prevalence of DNA repair gene mutations in localized prostate cancer according to clinical and pathologic features: association of Gleason score and tumor stage.
Prostate cancer and prostatic diseases - 1 Mar 2019
Marshall Catherine Handy, Fu Wei, Wang Hao, Baras Alexander S, Lotan Tamara L, Antonarakis Emmanuel S
Abstract excerpt
BACKGROUND: DNA repair gene mutations are present in 8-10% of localized prostate cancers. It is unknown whether this is influenced by clinicopathologic factors. METHODS: We interrogated localized prostate adenocarcinomas with tumor DNA sequencing information from the TCGA validated (n = 333) and Nature Genetics (n = 377) datasets. Homologous recombination repair genes included in our analysis were: ATM, BRCA1/2,...
Topics
- Alleles
- Biomarkers, Tumor
- DNA Repair
- Databases, Factual
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Male
- Mutation