Article
Germline DNA Damage Response Gene Mutations in Localized Prostate Cancer.
Medicina (Kaunas, Lithuania) - 30 Dec 2023
Januskevicius Tomas, Vaicekauskaite Ieva, Sabaliauskaite Rasa, Matulevicius Augustinas, Vezelis Alvydas, Ulys Albertas, Jarmalaite Sonata, Jankevicius Feliksas
Abstract excerpt
Background and Objectives: Germline DNA damage response (DDR) gene mutations correlate with increased prostate cancer (PCa) risk and a more aggressive form of the disease. DDR mutation testing is recommended for metastatic PCa cases, while eligible information about the mutations' burden in the early-stage localized PCa is still limited. This study is aimed at the prospective detection of DDR pathway mutations in...
Topics
- Male
- Humans
- Magnetic Resonance Imaging
- Prospective Studies
- Prostatic Neoplasms
- Mutation
- DNA Repair
- Germ Cells