Article
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
Nature immunology - 1 Jul 2021
Hiltensperger Michael, Beltrán Eduardo, Kant Ravi, Tyystjärvi Sofia, Lepennetier Gildas, Domínguez Moreno Helena, Bauer Isabel J, Grassmann Simon, Jarosch Sebastian, Schober Kilian, Buchholz Veit R, Kenet Selin, Gasperi Christiane, Öllinger Rupert, Rad Roland, Muschaweckh Andreas, Sie Christopher, Aly Lilian, Knier Benjamin, Garg Garima, Afzali Ali M, Gerdes Lisa Ann, Kümpfel Tania, Franzenburg Sören, Kawakami Naoto, Hemmer Bernhard, Busch Dirk H, Misgeld Thomas, Dornmair Klaus, Korn Thomas
Abstract excerpt
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or 'mixed' priming of helper T cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of priming in the systemic immune compartment is a determinant of helper T cell-induced immunopathology in remote organs. By site-specific in vivo labeling of...
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