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Article

In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition.

Acta neuropathologica communications - 7 Jun 2021

Lin Min, Mackie Phillip M, Shaerzadeh Fatima, Gamble-George Joyonna, Miller Douglas R, Martyniuk Chris J, Khoshbouei Habibeh

Abstract excerpt

Pathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson's disease (PD). Intracellular pathological inclusions of the protein α-synuclein within dopaminergic neurons are a cardinal feature of PD, but the mechanisms by which α-synuclein contributes to dopaminergic neuron vulnerability remain unknown. The inaccessibility to diseased tissue has been a...

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Identifiers

PMID: 34099060
DOI: 10.1186/s40478-021-01203-9
PMCID: PMC8185945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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