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Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication

7 Jun 2021

Abstract excerpt

Abstract Background Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to replication fidelity. It has been reported that CoVs exhibit variable sensitivity to nsp14-ExoN deficiency. Betacoronavirus murine hepatitis virus (MHV) and severe acute respiratory syndrome (SARS)-CoV were viable upon nsp14-ExoN deficiency. While...

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PMID: 34099051
DOI: 10.1186/s13578-021-00598-1

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