Crosstalk between CD180-overexpression macrophages and glioma cells worsens patient survival through malignant phenotype promotion and immunosuppressive regulation.

Abstract excerpt

BACKGROUND: Understanding the molecular mechanisms in immunosuppressive regulation is crucial for improving immunotherapeutic strategies. Macrophages, the major immune cells in tumor microenvironment (TME), play a dual role in tumor progression. CD180, primarily expressed in macrophages, remains unclear and requires further investigation. METHODS: RNA-seq data were obtained to analyze CD180 expression in gliomas...

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• Antigens, CD
• Brain Neoplasms
• Cell Line, Tumor
• Cell Proliferation
• Gene Expression Regulation, Neoplastic