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Article

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

12 Dec 2017

Abstract excerpt

Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second most common cause of liver failure. Mitochondrial dysfunction contributes to APAP-induced liver injury but the mechanism by which APAP causes hepatocyte toxicity is not completely understood. Therefore, we lack efficient therapeutic strategies to treat...

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PMID: 29233977
DOI: 10.1038/s41467-017-01970-x

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