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Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy.

Archives of biochemistry and biophysics - 15 Aug 2016

Kurahashi Toshihiro, Lee Jaeyong, Nabeshima Atsunori, Homma Takujiro, Kang Eun Sil, Saito Yuka, Yamada Sohsuke, Nakayama Toshiyuki, Yamada Ken-Ichi, Miyata Satoshi, Fujii Junichi

Abstract excerpt

Aldehyde reductase (AKR1A) plays a role in the biosynthesis of ascorbic acid (AsA), and AKR1A-deficient mice produce about 10-15% of the AsA that is produced by wild-type mice. We found that acetaminophen (AAP) hepatotoxicity was aggravated in AKR1A-deficient mice. The pre-administration of AsA in the drinking water markedly ameliorated the AAP hepatotoxicity in the AKR1A-deficient mice. Treatment of the mice...

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Identifiers

PMID: 27288086
DOI: 10.1016/j.abb.2016.06.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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