Article

Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen Overdose

2026-07-03

Abstract excerpt

An acetaminophen (APAP) overdose is the leading cause of drug-induced hepatotoxicity and acute liver failure (ALF) in the United States. While N-acetylcysteine (NAC), is highly effective when administered early after an overdose, its efficacy decreases with delayed administration. Since most patients present late to the clinic, there is an urgent need for novel late-acting therapeutic options to prevent progressio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4b38ab67-6018-58a9-a485-2584f5ba23ff
DOI: 10.64898/2026.06.29.735109

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen OverdoseDOI 10.64898/2026.06.29.735109Read

Egr1 confers protection against acetaminophen‑induced hepatotoxicity via transcriptional upregulating of Acaa2Semantic proximity Read

Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2-Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury.Semantic proximity Read

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or NecrosisSemantic proximity Read

CD36 deficiency ameliorates drug-induced acute liver injury in mice.Semantic proximity Read

Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in RatsSemantic proximity Read

The multiple mechanisms and modes of cell death after acetaminophen overdoseSemantic proximity Read

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.Semantic proximity Read

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male miceSemantic proximity Read

Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.Semantic proximity Read

A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.Semantic proximity Read

Application of High-Throughput Sequencing to Circulating microRNAs Reveals Novel Biomarkers for Drug-Induced Liver InjurySemantic proximity Read

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injurySemantic proximity Read