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Article

Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.

Scientific reports - 3 Jun 2021

Chen Jingyu, Debebe Anketse, Zeng Ni, Kopp Janel, He Lina, Sander Maike, Stiles Bangyan L

Abstract excerpt

SOX9 (Sex-determining region Y Box 9) is a well-characterized transcription factor that is a marker for progenitor cells in various tissues. In the liver, cells delineated by SOX9 are responsible for regenerating liver parenchyma when cell proliferation is impaired following chronic injury. However, whether these SOX9+ cells play a role in liver carcinogenesis has not been fully understood, although high SOX9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34083580
DOI: 10.1038/s41598-021-90958-1
PMCID: PMC8175600

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