Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration

14 Feb 2019

Abstract excerpt

Elucidation of the role of different cell lineages in the liver could offer avenues to drive liver regeneration. Previous studies showed that SOX9 + hepatocytes can differentiate into ductal cells after liver injuries. It is unclear whether SOX9 + hepatocytes are uni- or bipotent progenitors at a single-cell level during liver injury. Here, we developed a genetic tracing system to delineate the lineage potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to MicroRNA in disease regulation
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30773487
DOI: 10.1016/j.stemcr.2019.01.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver RegenerationPMID 30773487Read ↗

Sox9 and programming of liver and pancreatic progenitors.Semantic proximity Read ↗

Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.Semantic proximity Read ↗

Liver regeneration: Cellular origin and molecular mechanismsSemantic proximity Read ↗

Dynamics of hepatocyte-cholangiocyte cell-fate decisions during liver development and regenerationSemantic proximity Read ↗

Cellular and molecular basis of liver regenerationSemantic proximity Read ↗

Hepatocyte generation in liver homeostasis, repair, and regenerationSemantic proximity Read ↗

Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration.Semantic proximity Read ↗

Underlying potential: cellular and molecular determinants of adult liver repairSemantic proximity Read ↗

Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applicationsSemantic proximity Read ↗

Determining the fate of hepatic cells by lineage tracing: Facts and pitfallsSemantic proximity Read ↗

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiologySemantic proximity Read ↗

Lgr5 + pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.