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Article

Genetic abolishment of hepatocyte proliferation activates hepatic stem cells.

PloS one - 1 Jan 2012

Endo Yoko, Zhang Mingjun, Yamaji Sachie, Cang Yong

Abstract excerpt

Quiescent hepatic stem cells (HSCs) can be activated when hepatocyte proliferation is compromised. Chemical injury rodent models have been widely used to study the localization, biomarkers, and signaling pathways in HSCs, but these models usually exhibit severe promiscuous toxicity and fail to distinguish damaged and non-damaged cells. Our goal is to establish new animal models to overcome these limitations,...

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Identifiers

PMID: 22384083
DOI: 10.1371/journal.pone.0031846
PMCID: PMC3285627

Genes

DDB1

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