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Article

SOX9 Elevation in the Prostate Promotes Proliferation and Cooperates with <i>PTEN</i> Loss to Drive Tumor Formation

26 Jan 2010

Abstract excerpt

Dysregulation of tissue development pathways can contribute to cancer initiation and progression. In murine embryonic prostate epithelia, the transcription factor SOX9 is required for proper prostate development. In this study, we examined a role for SOX9 in prostate cancer in mouse and human. In Pten and Nkx3.1 mutant mice, cells with increased levels of SOX9 appeared within prostate epithelia at early stages of...

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Identifiers

PMID: 20103652
DOI: 10.1158/0008-5472.can-09-2370

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