Article
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
The New England journal of medicine - 3 Sept 2015
Claussnitzer Melina, Dankel Simon N, Kim Kyoung-Han, Quon Gerald, Meuleman Wouter, Haugen Christine, Glunk Viktoria, Sousa Isabel S, Beaudry Jacqueline L, Puviindran Vijitha, Abdennur Nezar A, Liu Jannel, Svensson Per-Arne, Hsu Yi-Hsiang, Drucker Daniel J, Mellgren Gunnar, Hui Chi-Chung, Hauner Hans, Kellis Manolis
Abstract excerpt
BACKGROUND: Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this association remains elusive. METHODS: We examined epigenomic data, allelic activity, motif conservation, regulator expression, and gene coexpression patterns, with...
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