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Article

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity.

Nature immunology - 1 Jan 2026

Lim Kok Haw Jonathan, Schulz Oliver, Lobon Irene, Castro-Dopico Tomas, Zapata Luis, Giampazolias Evangelos, Frederico Bruno, Castellanos Carlos A, Buck Michael D, Stainier William, Chakravarty Probir, Kelly Gavin, Rogers Neil C, Cardoso Ana, Lee Sonia, Vash Brian, Maiocco Stephanie, Mehta Raj, Strid Jessica, Turajlić Samra, Reis E Sousa Caetano

Abstract excerpt

Type 1 conventional dendritic cells (cDC1s) acquire and cross-present tumor antigens to prime CD8⁺ T cells. Whether this selects for specific neoantigens is unclear. DNGR-1 (CLEC9A), a cDC1 receptor for F-actin exposed on dead cells, promotes cross-presentation of cell-associated antigens. Here we show that DNGR-1-deficient mice develop chemically induced tumors more rapidly and at higher incidence, and these are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41482545
DOI: 10.1038/s41590-025-02354-w
PMCID: PMC12764433

Genes

CLEC9A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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