Llama single‐domain antibodies directed against nonconventional epitopes of tumor‐associated carcinoembryonic antigen absent from nonspecific cross‐reacting antigen

Abstract excerpt

Single‐domain antibodies (sdAbs), which occur naturally in camelids, are endowed with many characteristics that make them attractive candidates as building blocks to create new antibody‐related therapeutic molecules. In this study, we isolated from an immunized llama several high‐affinity sdAbs directed against human carcinoembryonic antigen (CEA), a heavily glycosylated tumor‐associated molecule expressed in a...

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