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Article

Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens.

Immunity - 19 May 2015

Hanč Pavel, Fujii Takashi, Iborra Salvador, Yamada Yurika, Huotari Jatta, Schulz Oliver, Ahrens Susan, Kjær Svend, Way Michael, Sancho David, Namba Keiichi, Reis e Sousa Caetano

Abstract excerpt

DNGR-1 is a C-type lectin receptor that binds F-actin exposed by dying cells and facilitates cross-presentation of dead cell-associated antigens by dendritic cells. Here we present the structure of DNGR-1 bound to F-actin at 7.7 Å resolution. Unusually for F-actin binding proteins, the DNGR-1 ligand binding domain contacts three actin subunits helically arranged in the actin filament, bridging over two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25979418
DOI: 10.1016/j.immuni.2015.04.009
PMCID: PMC5066845

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