Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Broad Cross-Presentation of the Hematopoietically Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted Immunotherapy

27 Oct 2012

Abstract excerpt

PR1 is a HLA-A2-restricted peptide that has been targeted successfully in myeloid leukemia with immunotherapy. PR1 is derived from the neutrophil granule proteases proteinase 3 (P3) and neutrophil elastase (NE), which are both found in the tumor microenvironment. We recently showed that P3 and NE are taken up and cross-presented by normal and leukemia-derived APCs, and that NE is taken up by breast cancer cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immunotherapy and Immune Responses
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23105141
DOI: 10.4049/jimmunol.1201221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Broad Cross-Presentation of the Hematopoietically Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted ImmunotherapyPMID 23105141Read ↗

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read ↗

Cancer and Innate Immune System InteractionsSemantic proximity Read ↗

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read ↗

Tumor Cell Cross Talk with Tumor-Associated Leukocytes Leads to Induction of Tumor Exosomal Fibronectin and Promotes Tumor ProgressionSemantic proximity Read ↗

Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigensSemantic proximity Read ↗

Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis.Semantic proximity Read ↗

The HLA crossroad in tumor immunology.Semantic proximity Read ↗

Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsetsSemantic proximity Read ↗

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.Semantic proximity Read ↗

Antigen Cross-Presentation of Immune ComplexesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.