Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.

doi:10.1038/s42003-021-02144-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.

Communications biology - 2 Jun 2021

Dowsett Joseph, Ferkingstad Egil, Rasmussen Line Jee Hartmann, Thørner Lise Wegner, Magnússon Magnús K, Sugden Karen, Thorleifsson Gudmar, Frigge Mike, Burgdorf Kristoffer Sølvsten, Ostrowski Sisse Rye, Sørensen Erik, Erikstrup Christian, Pedersen Ole Birger, Hansen Thomas Folkmann, Banasik Karina, Brunak Søren, Tragante Vinicius, Lund Sigrun Helga, Stefansdottir Lilja, Gunnarson Bjarni, Poulton Richie, Arseneault Louise, Caspi Avshalom, Moffitt Terrie E, Gudbjartsson Daníel, Eugen-Olsen Jesper, Stefánsson Hreinn, Stefánsson Kári, Ullum Henrik

Abstract excerpt

Soluble urokinase-type plasminogen activator receptor (suPAR) is a chronic inflammation marker associated with the development of a range of diseases, including cancer and cardiovascular disease. The genetics of suPAR remain unexplored but may shed light on the biology of the marker and its connection to outcomes. We report a heritability estimate of 60% for the variation in suPAR and performed a genome-wide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to C-Reactive Protein

Share to Chromosome Mapping

Share to Cohort Studies

Share to Inflammation Mediators

Share to Multifactorial Inheritance

Share to Quantitative Trait, Heritable

Share to Receptors, Urokinase Plasminogen Activator

Source

Open in PubMed Open full text

Identifiers

PMID: 34079037
DOI: 10.1038/s42003-021-02144-8
PMCID: PMC8172928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.PMID 34079037Read ↗

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.Semantic proximity Read ↗

Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosisSemantic proximity Read ↗

Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular diseaseSemantic proximity Read ↗

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.Semantic proximity Read ↗

Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-Omics for Precision Medicine (TOPMed) ConsortiumSemantic proximity Read ↗

Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium.Semantic proximity Read ↗

MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.Semantic proximity Read ↗

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.Semantic proximity Read ↗

The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction.Semantic proximity Read ↗

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.Semantic proximity Read ↗

Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.Semantic proximity Read ↗

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.