Article
Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium.
Human molecular genetics - 6 Aug 2024
Jiang Min-Zhi, Gaynor Sheila M, Li Xihao, Van Buren Eric, Stilp Adrienne, Buth Erin, Wang Fei Fei, Manansala Regina, Gogarten Stephanie M, Li Zilin, Polfus Linda M, Salimi Shabnam, Bis Joshua C, Pankratz Nathan, Yanek Lisa R, Durda Peter, Tracy Russell P, Rich Stephen S, Rotter Jerome I, Mitchell Braxton D, Lewis Joshua P, Psaty Bruce M, Pratte Katherine A, Silverman Edwin K, Kaplan Robert C, Avery Christy, North Kari E, Mathias Rasika A, Faraday Nauder, Lin Honghuang, Wang Biqi, Carson April P, Norwood Arnita F, Gibbs Richard A, Kooperberg Charles, Lundin Jessica, Peters Ulrike, Dupuis Josée, Hou Lifang, Fornage Myriam, Benjamin Emelia J, Reiner Alexander P, Bowler Russell P, Lin Xihong, Auer Paul L, Raffield Laura M
Abstract excerpt
Inflammation biomarkers can provide valuable insight into the role of inflammatory processes in many diseases and conditions. Sequencing based analyses of such biomarkers can also serve as an exemplar of the genetic architecture of quantitative traits. To evaluate the biological insight, which can be provided by a multi-ancestry, whole-genome based association study, we performed a comprehensive analysis of 21...
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