Article
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
Blood - 6 Dec 2012
Huang Jie, Sabater-Lleal Maria, Asselbergs Folkert W, Tregouet David, Shin So-Youn, Ding Jingzhong, Baumert Jens, Oudot-Mellakh Tiphaine, Folkersen Lasse, Johnson Andrew D, Smith Nicholas L, Williams Scott M, Ikram Mohammad A, Kleber Marcus E, Becker Diane M, Truong Vinh, Mychaleckyj Josyf C, Tang Weihong, Yang Qiong, Sennblad Bengt, Moore Jason H, Williams Frances M K, Dehghan Abbas, Silbernagel Günther, Schrijvers Elisabeth M C, Smith Shelly, Karakas Mahir, Tofler Geoffrey H, Silveira Angela, Navis Gerjan J, Lohman Kurt, Chen Ming-Huei, Peters Annette, Goel Anuj, Hopewell Jemma C, Chambers John C, Saleheen Danish, Lundmark Per, Psaty Bruce M, Strawbridge Rona J, Boehm Bernhard O, Carter Angela M, Meisinger Christa, Peden John F, Bis Joshua C, McKnight Barbara, Öhrvik John, Taylor Kent, Franzosi Maria Grazia, Seedorf Udo, Collins Rory, Franco-Cereceda Anders, Syvänen Ann-Christine, Goodall Alison H, Yanek Lisa R, Cushman Mary, Müller-Nurasyid Martina, Folsom Aaron R, Basu Saonli, Matijevic Nena, van Gilst Wiek H, Kooner Jaspal S, Hofman Albert, Danesh John, Clarke Robert, Meigs James B, Kathiresan Sekar, Reilly Muredach P, Klopp Norman, Harris Tamara B, Winkelmann Bernhard R, Grant Peter J, Hillege Hans L, Watkins Hugh, Spector Timothy D, Becker Lewis C, Tracy Russell P, März Winfried, Uitterlinden Andre G, Eriksson Per, Cambien Francois, Morange Pierre-Emmanuel, Koenig Wolfgang, Soranzo Nicole, van der Harst Pim, Liu Yongmei, O'Donnell Christopher J, Hamsten Anders
Abstract excerpt
We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (P < 5 × 10(-8)) single nucleotide...
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