Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.

Circulation. Genomic and precision medicine - 1 Dec 2021

Olson Nels C, Raffield Laura M, Moxley Anne H, Miller-Fleming Tyne W, Auer Paul L, Franceschini Nora, Ngo Debby, Thornton Timothy A, Lange Ethan M, Li Yun, Nickerson Deborah A, Zakai Neil A, Gerszten Robert E, Cox Nancy J, Correa Adolfo, Mohlke Karen L, Reiner Alexander P

Abstract excerpt

BACKGROUND: suPAR (Soluble urokinase plasminogen activator receptor) has emerged as an important biomarker of coagulation, inflammation, and cardiovascular disease (CVD) risk. The contribution of suPAR to CVD risk and its genetic influence in Black populations have not been evaluated. METHODS: We measured suPAR in 3492 Black adults from the prospective, community-based JHS (Jackson Heart Study). Cross-sectional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases
Share to Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Receptors, Urokinase Plasminogen Activator

Source

Open in PubMed Open full text

Identifiers

PMID: 34706549
DOI: 10.1161/CIRCGEN.121.003421
PMCID: PMC8692389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.PMID 34706549Read ↗

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.Semantic proximity Read ↗

Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular diseaseSemantic proximity Read ↗

The role of rare variants in systolic blood pressure: analysis of ExomeChip data in HyperGEN African Americans.Semantic proximity Read ↗

Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosisSemantic proximity Read ↗

Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.Semantic proximity Read ↗

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.Semantic proximity Read ↗

Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study.Semantic proximity Read ↗

Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.Semantic proximity Read ↗

TESTING POPULATION-SPECIFIC QUANTITATIVE TRAIT ASSOCIATIONS FOR CLINICAL OUTCOME RELEVANCE IN A BIOREPOSITORY LINKED TO ELECTRONIC HEALTH RECORDS: LPA AND MYOCARDIAL INFARCTION IN AFRICAN AMERICANS.Semantic proximity Read ↗

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.Semantic proximity Read ↗

Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project.Semantic proximity Read ↗

Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.