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Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis

4 Oct 2022

Abstract excerpt

People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which are strongly associated with cardiovascular outcomes. We assessed suPAR's pathogenic involvement in atherosclerosis using epidemiologic, genetic, and experimental approaches. We found serum suPAR...

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PMID: 36194491
DOI: 10.1172/jci158788

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