Article
A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.
American journal of human genetics - 5 Jan 2017
Carmona F David, Vaglio Augusto, Mackie Sarah L, Hernández-Rodríguez José, Monach Paul A, Castañeda Santos, Solans Roser, Morado Inmaculada C, Narváez Javier, Ramentol-Sintas Marc, Pease Colin T, Dasgupta Bhaskar, Watts Richard, Khalidi Nader, Langford Carol A, Ytterberg Steven, Boiardi Luigi, Beretta Lorenzo, Govoni Marcello, Emmi Giacomo, Bonatti Francesco, Cimmino Marco A, Witte Torsten, Neumann Thomas, Holle Julia, Schönau Verena, Sailler Laurent, Papo Thomas, Haroche Julien, Mahr Alfred, Mouthon Luc, Molberg Øyvind, Diamantopoulos Andreas P, Voskuyl Alexandre, Brouwer Elisabeth, Daikeler Thomas, Berger Christoph T, Molloy Eamonn S, O'Neill Lorraine, Blockmans Daniel, Lie Benedicte A, Mclaren Paul, Vyse Timothy J, Wijmenga Cisca, Allanore Yannick, Koeleman Bobby P C, Barrett Jennifer H, Cid María C, Salvarani Carlo, Merkel Peter A, Morgan Ann W, González-Gay Miguel A, Martín Javier
Abstract excerpt
Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analyzed in 2,134 case subjects and 9,125 unaffected individuals from ten independent...
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