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MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank.

Annals of the rheumatic diseases - 1 Jul 2018

Li Xue, Meng Xiangrui, Spiliopoulou Athina, Timofeeva Maria, Wei Wei-Qi, Gifford Aliya, Shen Xia, He Yazhou, Varley Tim, McKeigue Paul, Tzoulaki Ioanna, Wright Alan F, Joshi Peter, Denny Joshua C, Campbell Harry, Theodoratou Evropi

Abstract excerpt

OBJECTIVES: We aimed to investigate the role of serum uric acid (SUA) level in a broad spectrum of disease outcomes using data for 120 091 individuals from UK Biobank. METHODS: We performed a phenome-wide association study (PheWAS) to identify disease outcomes associated with SUA genetic risk loci. We then implemented conventional Mendelianrandomisation (MR) analysis to investigate the causal relevance between...

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PMID: 29437585
DOI: 10.1136/annrheumdis-2017-212534
PMCID: PMC6029646

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