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Article

The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction.

Frontiers in immunology - 1 Jan 2024

Yatsenko Tetiana, Rios Ricardo, Nogueira Tatiane, Salama Yousef, Takahashi Satoshi, Adachi Eisuke, Tabe Yoko, Hattori Nobutaka, Osada Taro, Naito Toshio, Takahashi Kazuhisa, Hattori Koichi, Heissig Beate

Abstract excerpt

Introduction: Plasminogen activator inhibitor-1 (PAI-1) is linked to thrombosis and endothelial dysfunction in severe COVID-19. The +43 G>A PAI-1 and 4G/5G promoter polymorphism can influence PAI-1 expression. The 4G5G PAI-1 promoter gene polymorphism constitutes the 4G4G, 4G5G, and 5G5G genotypes. However, the impact of PAI-1 polymorphisms on disease severity or endothelial dysfunction remains unclear. Methods:...

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Aged
COVID-19
Interleukin-1beta
Leukocytes, Mononuclear
Plasminogen Activator Inhibitor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Severity of Illness Index

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Open in PubMed Open full text

Identifiers

PMID: 39281671
DOI: 10.3389/fimmu.2024.1445294
PMCID: PMC11392769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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