Article
Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study.
International journal of molecular sciences - 5 Nov 2023
Buianova Anastasiia A, Proskura Mariia V, Cheranev Valery V, Belova Vera A, Shmitko Anna O, Pavlova Anna S, Vasiliadis Iuliia A, Suchalko Oleg N, Rebrikov Denis V, Petrosyan Edita K, Korostin Dmitriy O
Abstract excerpt
IgA nephropathy (IgAN) is an autoimmune disorder which is believed to be non-monogenic. We performed an exome-wide association study of 70 children with IgAN and 637 healthy donors. The HLA allele frequencies were compared between the patients and healthy donors from the bone marrow registry of the Pirogov University. We tested 78,020 gene markers for association and performed functional enrichment analysis and...
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