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Article

Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis.

Frontiers of medicine - 1 Oct 2024

Li Ming, Hao Xingjie, Shi Dianchun, Cheng Shanshan, Zhong Zhong, Cai Lu, Jiang Minghui, Ding Lin, Ding Lanbo, Wang Chaolong, Yu Xueqing

Abstract excerpt

Although many susceptibility loci for IgA nephropathy (IgAN) have been identified, they only account for 11.0% of the overall IgAN variance. We performed a large genome-wide meta-analysis of IgAN in Han Chinese with 3616 cases and 10 417 controls to identify additional genetic loci of IgAN. Considering that inflammatory bowel disease (IBD) and asthma might share an etiology of dysregulated mucosal immunity with...

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Identifiers

PMID: 39343836
DOI: 10.1007/s11684-024-1086-2

Genes

CD4
PNKD
SCAF8
TRAF3
TXNL4B
UBE2L3

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