Article

GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy

2021-11-20

Abstract excerpt

<h4>ABSTRACT</h4> IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular deposition of IgA. We performed a genome-wide association study involving 10,146 kidney biopsy-diagnosed IgAN cases and 28,751 matched controls across 17 international cohorts. We defined 30 independent genome-wide significant risk loci jointly explaining 11% of disease risk. A total of 16 loci were novel, includ...

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Literature Corpus work: a19e3d4a-0b91-56e8-abdf-495645d73283
DOI: 10.1101/2021.11.19.21265383

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