Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.

doi:10.1681/ASN.2019080799

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Article

Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Dec 2020

Li Ming, Wang Ling, Shi Dian-Chun, Foo Jia-Nee, Zhong Zhong, Khor Chiea-Chuen, Lanzani Chiara, Citterio Lorena, Salvi Erika, Yin Pei-Ran, Bei Jin-Xin, Wang Li, Liao Yun-Hua, Chen Jian, Chen Qin-Kai, Xu Gang, Jiang Geng-Ru, Wan Jian-Xin, Chen Meng-Hua, Chen Nan, Zhang Hong, Zeng Yi-Xin, Liu Zhi-Hong, Liu Jian-Jun, Yu Xue-Qing

Abstract excerpt

BACKGROUND: Eighteen known susceptibility loci for IgAN account for only a small proportion of IgAN risk. METHODS: Genome-wide meta-analysis was performed in 2628 patients and 11,563 controls of Chinese ancestry, and a replication analysis was conducted in 6879 patients and 9019 controls of Chinese descent and 1039 patients and 1289 controls of European ancestry. The data were used to assess the association of...

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PMID: 32912934
DOI: 10.1681/ASN.2019080799
PMCID: PMC7790208

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