Article
The importance of mitochondria in the tumourigenic phenotype: gliomas as the paradigm (review).
International journal of molecular medicine - 1 Feb 2011
Liang Bertrand C, Grootveld Martin
Abstract excerpt
Cancer arises from the accumulation of nuclear and cytoplasmic abnormalities, a phenomenon allowing for the expression of the tumourigenic phenotype. Gliomas represent the most frequently diagnosed tumours of the central nervous system in adults. Warburg hypothesized the importance of glycolysis in cancer cells, and implicated additional roles of mitochondria in neoplasia. Recent data have shown the importance of...
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