Article
KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
International journal of molecular sciences - 9 May 2021
West James D, Austin Eric D, Rizzi Elise M, Yan Ling, Tanjore Harikrishna, Crabtree Amber L, Moore Christy S, Muthian Gladson, Carrier Erica J, Jacobson David A, Hamid Rizwan, Kendall Peggy L, Majka Susan, Rathinasabapathy Anandharajan
Abstract excerpt
Loss of function KCNK3 mutation is one of the gene variants driving hereditary pulmonary arterial hypertension (PAH). KCNK3 is expressed in several cell and tissue types on both membrane and endoplasmic reticulum and potentially plays a role in multiple pathological process associated with PAH. However, the role of various stressors driving the susceptibility of KCNK3 mutation to PAH is unknown. Hence, we exposed...
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