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Article

The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery.

Journal of the American Heart Association - 9 Sept 2017

Bohnen Michael S, Roman-Campos Danilo, Terrenoire Cecile, Jnani Jack, Sampson Kevin J, Chung Wendy K, Kass Robert S

Abstract excerpt

BACKGROUND: Heterozygous loss of function mutations in the KCNK3 gene cause hereditary pulmonary arterial hypertension (PAH). KCNK3 encodes an acid-sensitive potassium channel, which contributes to the resting potential of human pulmonary artery smooth muscle cells. KCNK3 is widely expressed in the body, and dimerizes with other KCNK3 subunits, or the closely related, acid-sensitive KCNK9 channel. METHODS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Tandem Pore Domain

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Source

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Identifiers

PMID: 28889099
DOI: 10.1161/JAHA.117.006465
PMCID: PMC5634293

Genes

KCNK3
PAH
KCNK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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