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Article

Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation.

Lymphatic research and biology - 1 Feb 2018

Glaser Kathryn, Dickie Peter, Neilson Derek, Osborn Alexander, Dickie Belinda Hsi

Abstract excerpt

BACKGROUND: Lymphatic endothelial cells (LECs) derived from lymphatic malformations (LMs) bear activated PIK3CA alleles yet display an inflammatory gene expression profile. A basis for the inflammatory phenotype was sought by screening for coexisting somatic mutations. METHODS AND RESULTS: Fourteen independent LEC populations bearing activated PIK3CA alleles were isolated from LM. These were characterized by the...

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Identifiers

PMID: 29346025
DOI: 10.1089/lrb.2017.0033

Genes

VEGFC
ANGPTL4
ANK3
FITM2
MTA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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