Article
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Circulation - 5 Apr 2016
Antigny Fabrice, Hautefort Aurélie, Meloche Jolyane, Belacel-Ouari Milia, Manoury Boris, Rucker-Martin Catherine, Péchoux Christine, Potus François, Nadeau Valérie, Tremblay Eve, Ruffenach Grégoire, Bourgeois Alice, Dorfmüller Peter, Breuils-Bonnet Sandra, Fadel Elie, Ranchoux Benoît, Jourdon Philippe, Girerd Barbara, Montani David, Provencher Steeve, Bonnet Sébastien, Simonneau Gérald, Humbert Marc, Perros Frédéric
Abstract excerpt
BACKGROUND: Mutations in the KCNK3 gene have been identified in some patients suffering from heritable pulmonary arterial hypertension (PAH). KCNK3 encodes an outward rectifier K(+) channel, and each identified mutation leads to a loss of function. However, the pathophysiological role of potassium channel subfamily K member 3 (KCNK3) in PAH is unclear. We hypothesized that loss of function of KCNK3 is a hallmark...
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