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Article

Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload.

Cardiovascular research - 1 Nov 2021

Lambert Mélanie, Mendes-Ferreira Pedro, Ghigna Maria-Rosa, LeRibeuz Hélène, Adão Rui, Boet Angèle, Capuano Véronique, Rucker-Martin Catherine, Brás-Silva Carmen, Quarck Rozenn, Domergue Valérie, Vachiéry Jean-Luc, Humbert Marc, Perros Frédéric, Montani David, Antigny Fabrice

Abstract excerpt

AIMS: Pulmonary hypertension (PH) is a common complication of left heart disease (LHD, Group 2 PH) leading to right ventricular (RV) failure and death. Several loss-of-function (LOF) mutations in KCNK3 were identified in pulmonary arterial hypertension (PAH, Group 1 PH). Additionally, we found that KCNK3 dysfunction is a hallmark of PAH at pulmonary vascular and RV levels. However, the role of KCNK3 in the...

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Share to Potassium Channels, Tandem Pore Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33483721
DOI: 10.1093/cvr/cvab016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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