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Article

KCNK3 Variants Are Associated With Hyperaldosteronism and Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2016

Manichaikul Ani, Rich Stephen S, Allison Matthew A, Guagliardo Nick A, Bayliss Douglas A, Carey Robert M, Barrett Paula Q

Abstract excerpt

Blood pressure (BP) is a complex trait that is the consequence of an interaction between genetic and environmental determinants. Previous studies have demonstrated increased BP in mice with global deletion of TASK-1 channels contemporaneous with diverse dysregulation of aldosterone production. In humans, genome-wide association studies in ≈100 000 individuals of European, East Asian, and South Asian ancestry...

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Source

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Identifiers

PMID: 27296998
DOI: 10.1161/HYPERTENSIONAHA.116.07564
PMCID: PMC4945430

Genes

KCNK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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