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Article

Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals.

Molecular and cellular endocrinology - 5 Dec 2015

Chen Andrew X, Nishimoto Koshiro, Nanba Kazutaka, Rainey William E

Abstract excerpt

Three potassium channels have been associated with primary aldosteronism (PA) in rodents and humans: KCNK3 (TASK-1), KCNK9 (TASK-3), and KCNJ5 (Kir3.4). Mice with deficiency in Kcnk3 and Kcnk9 have elevated aldosterone production and blood pressure. In humans, adrenal tumors with somatic mutations in KCNJ5 cause PA. However, there are very few reports on the expression patterns of these genes in humans versus...

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Source

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Identifiers

PMID: 26375812
DOI: 10.1016/j.mce.2015.09.011
PMCID: PMC4646165

Genes

KCNJ5
KCNK3
KCNK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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