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Article

High maternal-fetal HLA eplet compatibility is associated with severe manifestation of preeclampsia

3 Nov 2023

Abstract excerpt

Introduction: Preeclampsia is responsible for more than 70 000 and 500 000 maternal and fetal deaths, respectively each year. Incomplete remodelling of the spiral arteries in placenta is the most accepted theory of preeclampsia pathogenesis. However, the process is complexed with immunological background, as pregnancy resembles allograft transplantation. Fetus expresses human leukocyte antigens (HLA) inherited...

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PMID: 38022600
DOI: 10.3389/fimmu.2023.1272021

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