Article
Maternal-Foetal HLA-DQB1 Incompatibility Is Associated With Pregnancy-Induced Hypertensive Disorders in a Genetically Isolated Population.
HLA - 1 Aug 2025
Hof Liseanne J Van't, van der Hoorn Marie-Louise P, Migdis Selena, Haasnoot Geert W, Peereboom Emma T M, Spierings Eric, van der Linden Pieter J E, Anholts Jacqueline D H, de Vreede Heleen, Ottenhof Winnie, Roelen Dave L, Eikmans Michael, Mathijssen Inge B, Lashley Lisa E E L O
Abstract excerpt
In pregnancy, semi-allogenic foetal trophoblasts express a specific HLA profile mediating maternal leukocyte contact, crucial for placentation. Paradoxically, maternal immunomodulation requires foetal antigen recognition, especially involving certain HLA molecules. Pre-eclampsia, a severe hypertensive complication, has been linked to antigenic similarity. Previously, we showed no selection for HLA...
Read the complete abstract on PubMedTopics
- Humans
- Female
- Pregnancy
- Hypertension, Pregnancy-Induced
- HLA-DQ beta-Chains