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Article

The role of TRIB1 in lipid metabolism; from genetics to pathways.

Biochemical Society transactions - 1 Oct 2015

Iwamoto Sadahiko, Boonvisut Supichaya, Makishima Saho, Ishizuka Yuumi, Watanabe Kazuhisa, Nakayama Kazuhiro

Abstract excerpt

The plasma concentration of lipids is a heritable risk factor for the development of atherosclerosis and related coronary artery diseases (CAD). Mammalian tribbles homologue 1 (TRIB1) is a human locus, the downstream linkage disequilibrium (LD) block of which affects plasma low-density lipoprotein (LDL)-associated cholesterol, triglyceride (TG) levels and CAD across multiple ethnic groups. In addition,...

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Topics

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Share to Intracellular Signaling Peptides and Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Serine-Threonine Kinases

Share to Regulatory Sequences, Nucleic Acid

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Source

Identifiers

PMID: 26517924
DOI: 10.1042/BST20150094

Genes

TRIB1
CAD
MTTP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of TRIB1 in lipid metabolism; from genetics to pathways.PMID 26517924Read ↗

Tribbles-1: a novel regulator of hepatic lipid metabolism in humansSemantic proximity Read ↗

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Trouble With Tribbles-1Semantic proximity Read ↗

TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.Semantic proximity Read ↗

The A>T polymorphism of the tribbles homolog 1 gene is associated with serum triglyceride concentrations in Japanese community-dwelling women.Semantic proximity Read ↗

The long non-coding RNA<i>TRIB1AL</i>links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespanSemantic proximity Read ↗

TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.Semantic proximity Read ↗

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.Semantic proximity Read ↗

Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in MiceSemantic proximity Read ↗

TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans.Semantic proximity Read ↗

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