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Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in mice

17 Nov 2010

Abstract excerpt

Recent genome-wide association studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated with lower levels of plasma triglyceride (TG) and LDL cholesterol (LDL-C), higher levels of HDL-C, as well as decreased risk for myocardial infarction. This locus contains only one annotated gene, tribbles homolog 1 (TRIB1), which has not previously been implicated in lipoprotein...

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PMID: 21084752
DOI: 10.1172/jci44213

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Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in micePMID 21084752Read ↗

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TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.Semantic proximity Read ↗

The A>T polymorphism of the tribbles homolog 1 gene is associated with serum triglyceride concentrations in Japanese community-dwelling women.Semantic proximity Read ↗

Trib1 deficiency causes brown adipose respiratory chain depletion and mitochondrial disorderSemantic proximity Read ↗

TRIB1 and TRPS1 Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid ConcentrationsSemantic proximity Read ↗

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