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Article

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes.

EBioMedicine - 1 Jun 2021

Julian Thomas H, Glascow Nicholas, Barry A Dylan Fisher, Moll Tobias, Harvey Calum, Klimentidis Yann C, Newell Michelle, Zhang Sai, Snyder Michael P, Cooper-Knock Johnathan, Shaw Pamela J

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS is determined by gene-environment interactions and improved understanding of these interactions may lead to effective personalised medicine. The role of physical exercise in the development of ALS is currently controversial. METHODS: First, we dissected the exercise-ALS relationship in a series of two-sample...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34051439
DOI: 10.1016/j.ebiom.2021.103397
PMCID: PMC8170114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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