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Article

Physical activity and amyotrophic lateral sclerosis: a Mendelian randomization study.

Neurobiology of aging - 1 Sept 2021

Zhang Gan, Zhang Linjing, Tang Lu, Xia Kailin, Huang Tao, Fan Dongsheng

Abstract excerpt

Physical activity (PA) participation has been noted as a potential risk factor for amyotrophic lateral sclerosis (ALS) for decades. However, current studies have been unable to pinpoint the exact relationship between them. Here, we used 2-sample Mendelian randomization (MR), a novel method to systematically investigate causal relationships between PA and ALS. Summary-level data for accelerometer-based and...

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PMID: 34023151
DOI: 10.1016/j.neurobiolaging.2021.04.010

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