Article

Rare and common variant analyses of amyotrophic lateral sclerosis in the French-Canadian genome

2022-08-13

Abstract excerpt

<h4>ABSTRACT</h4> The genetic etiology of ALS includes few rare, large-effect variants and potentially many common, small-effect variants per case. The genetic risk liability for ALS might require a threshold comprised of a certain amount of variants. Here, we tested the degree to which risk for ALS was affected by rare variants in ALS genes, polygenic risk score, or both. 335 ALS cases and 356 controls from Québe...

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Literature Corpus work: 2ead6250-1eb5-56a8-ba55-959a40b141e2
DOI: 10.1101/2022.08.11.22278628

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