Article
Amyotrophic lateral sclerosis as a complex genetic disease.
Biochimica et biophysica acta - 1 Jan 2000
Simpson Claire L, Al-Chalabi Ammar
Abstract excerpt
In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin...
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