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Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study

27 Jan 2021

Abstract excerpt

BACKGROUND: Physical activity has been hypothesized to play a protective role in neurodegenerative diseases. However, effect estimates previously derived from observational studies were prone to confounding or reverse causation. METHODS: ) from 2 largest meta-analyses of about 91,100 UK Biobank participants. Summary statistics for AD, PD, and ALS were retrieved from the up-to-date studies in European ancestry led...

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PMID: 33515719
DOI: 10.1016/j.jshs.2021.01.008

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